IDA can cause a complex burden1–8
IDA places a substantial burden on patients1,2
Anaemia affects around a third of the world’s population and half of cases are due to ID1
IDA negatively impacts many aspects of patients’ HRQoL2
Oral ferrous iron salts are 2.3 times more likely to cause gastrointestinal AEs vs placebo3
The most common gastrointestinal AEs with oral
ferrous iron salts were:3
- Nausea
- Abdominal pain
- Diarrhoea
- Constipation
There is no significant dose-response effect on gastrointestinal AEs with oral ferrous iron salts3
IV iron can be time-consuming and resource-intensive to administer4–8
Each infusion costs healthcare professionals time for administration and monitoring, and many patients also have the extra burden of travel time and expenses4–9
IV iron can only be administered by staff trained to identify and manage anaphylactic reactions, and in settings where full resuscitation facilities are available4–8
AE, adverse event; HRQoL, health-related quality of life; ID, iron deficiency; IDA, iron deficiency anaemia; IV, intravenous.
References:
- Lopez A, et al. Lancet 2016;387:907–916.
- Strauss WE, et al. JCSO 2016;14(8):342–350.
- Tolkien Z, et al. PLoS One 2015;10(2):e0117383.
- CosmoFer® UK Summary of Product Characteristics. January 2020. Available at: https://www.medicines.org.uk/emc/product/48. Accessed April 2021.
- Diafer® UK Summary of Product Characteristics. August 2020. Available at: https://www.medicines.org.uk/emc/product/5324. Accessed April 2021.
- Ferinject® UK Summary of Product Characteristics. October 2020. Available at: https://www.medicines.org.uk/emc/product/5910. Accessed April 2021.
- Monofer® UK Summary of Product Characteristics. May 2020. Available at: https://www.medicines.org.uk/emc/product/5676. Accessed April 2021.
- Venofer® UK Summary of Product Characteristics. December 2020. Available at: https://www.medicines.org.uk/emc/product/5911. Accessed April 2021.
- Bager P, et al. J Crohns Colitis 2010;4(4):427–430.
